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Contraindicated (1)pentobarbital will lessen the level or impact of lumacaftor/ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will minimize the extent or effect of diclofenac by impacting hepatic enzyme CYP2C9/ten metabolism. Insignificant/Importance Not known.pentobarbital will minimize the level or result of pare